Sciatica or sciatic neuralgia is a common condition in which one of the spinal nerve roots of the sciatic nerve is compressed resulting in lower back, buttock and leg pain. Sciatic nerve is a large nerve derived from 5 spinal nerve roots: L4, L5, S1, S2 and S3. It runs from the lumbar spine through the buttock down the leg and the foot on the posterior aspect. There is one sciatic nerve on each side of the body. Typically, only one side of the body is affected. A typical sciatica pain is described as a.
Sharp shooting pain in the lower back, down the buttock, thigh and leg on one side of the body. There may also be numbness, burning and tingling sensations. The pain can get worse with sitting, moving, sneezing, or coughing. The patterns of pain depend on which nerve root is compressed, and follow the dermatome distribution. The most common cause of sciatica is a herniated spinal disc. The spinal disc is a soft elastic cushion that sits in between the vertebrae of the spine. With age, the discs become rigid.
And may crack, the gellike center of the disc may protrude out and become a herniation outside the normal boundaries of the disc. Disc herniation presses on the nerve root as it exits the spine. In majority of the cases the condition resolves by itself after a few weeks of rest and conservative treatment. Pain relief, nonsteroidal antiinflammatory drugs and muscle relaxants may be prescribed. Stretching exercises and physical therapy may be recommended. Surgery may be needed if the pain doesnt.
Why Cant We Reverse Nerve Damage
Every year, tens of millions of americans suffer from nerve damage, some irreparably so. Science can heal bones, grow new organs and even restore our microbiomes, but why is it so hard to fix our nerves? Hey guys Lissette here for DNews The human body posses a remarkable ability to heal. Bones refuse, skin wounds mend, and the immune system adapts to infection, after infection. But theres one area of.
The body that struggles to recover after an injury: the nervous system. nerve damage can be some of the most debilitating and permanent type of injury. The nervous system is an incredibly complex network used to send electrical information throughout your body. It can basically be divided into two sections. With the brain and spinal cord making up the central nervous system or CNS. and the nerves made up of fibers of sensory and motor neurons comprising the peripheral nervous system.
Each cell in the nervous system from the tip of your finger up your arm, up your spinal column, into your brain, is very specialized. And each has a unique function on the pathway, like a circuit. If one these gets cut or injured, its hard for an exact replacement cell to be put in in the right spot. Think about when you get a cut on your skin. If the cut goes deep enough, exact replicas of cells won’t cover the wound, instead fibrous tissues form. which we call scars. And scars are part of the problem in regrowing nerves, they.
Often get in the way especially in the case of spinal cord injuries. as part of the cns, spinal cord injuries are notoriously difficult to heal; partially because of the way nerve cells in the CNS are made. According to the book, Results and Problems in Cell Differentiation, the CNS also has certain proteins that weirdly, inhibit cell regeneration. While this might sound like a bad idea, its hugely beneficial overall to the formation of the CNS. These cells need.
To grow exactly where they are supposed to, just one out of place could be bad. like. think of an electrical circuit, each unit has to be in a specific order in specific place to work. If one is out of place, the integrity of the CNS is compromised. Neurons in the CNS also lack certain cleaning cells. Nerve cells are made up of many parts, but they send signals through threads covered in a protective sheet of myelin. These threads are called axons. Axons are the long part of the cell that reaches out to the cell next.
To it to send information down the line. like arms handing the bucket down the line in a bucket brigade. So these are obviously super important and need protecting. Thats where the Schwann cells come in. which are only found in the Peripheral nervous system. Schwann cells, which arent neurons but GLEEL cells, produce the myelin that help protect the axons. But, a study published in The Journal of Cell Biology found they also clean up damaged nerves making way for the healing process to take place and.
New nerves to be formed. but the problem is. these schwann cells are missing from the cns. What they have instead are myelin producing cells called oligodendrocytes. But these cells dont clean up damaged nerve cells at all. Which is part of the problem. So unfortunately, according to Richard G. Fessler professor at Rush University Medical Center There are currently no therapies which successfully reverse the damage from injuries to the spinal cord. But research is currently underway to examine the potential success.
Of stem cell treatment, where stem cells are injected directly at the injury site. still, it will take a few years to see the results of such trials. But there are times your body can regenerate nerves. The peripheral nervous system doesnt have the same blocking proteins that the CNS has, and Schwann cells help heal the damage. So its able to regrow nerves, albeit slowly. For instance, if you cut a nerve into your shoulder, it could take a year to regrow. By that time.the muscles in your arms could.